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Home / Proteins & Peptide

SHP-2, His-Tag

SKU : BHP18200712

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BPS Bioscience

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Mfr.No.	79018
Description	Human recombinant SHP-2, also known as PTPN11 (protein tyrosine phosphatase N11), full length (a.a. 2-593 (end) with N-terminal His-tag, Genbank accession number NM_002834, MW=70 kDa, expressed in an E. coli expression system. Specific activity: >50 pmol/min/ ug
Background	Mammalian PTPases can be subdivided into 1 of 2 broad categories: transmembrane receptor PTPases and intracellular PTPases. PTPN11 is one of the 2 closely related mammalian intracellular PTPases whose sequences encode 2 tandem SRC homology 2 (SH2) domains that are located at the amino-terminal side of a single PTPase catalytic domain. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration.
Immunogen Region	2-593
Tag	N-terminal GST-tag
Formulation	40mM Tris pH 8.0, 110mM NaCl, 2.2mM KCl, 0.04% Tween-20 and 20% glycerol.
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	50mM HEPES, pH 7.4, 100mM NaCl, 2mM EDTA, 3mM DTT, 5mM PNPP substrate, 30 min at 30°C. Absorbance is measured at 405nM. Avoid freeze/thaw cycles.
GenBank	NM_002834
Mw(kda)	70 kDa

Synonyms	SHP2, CFC, NS1, BPTP3, PTP2C, PTP-1D, SH-PTP2, SH-PTP3, MGC14433
Uniprot	Q06124

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C. Avoid freeze/thaw cycles. Protein may be diluted to>=100 ug/ml in PBS + glycerol and stored at -80°C.

Reference	1. B.G. Neel et al. Trends Biochem. Sci. (2003) 28: 2842. J.V. Ravetch & L.L. Lanier Science (2000) 290: 84

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200712	79018	20 ug	$423.50		Add to Cart

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