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Home / Proteins & Peptide

SHP-1(PTPN6), GST-tag

SKU : BHP18200033

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Mfr.No.	30021
Description	Protein tyrosine phosphatase SHP-1, also known as PTPN6 (GenBank accession number NM_080549), full length, with N-terminal GST-tag, MW=95 kDa, expressed in an E. coli expression system. Specific activity: 1 U/ug Unit definition: One unit will hydrolyze 1 pmol p-nitrophenyl phosphate per minute at pH 7.4 and 30°C.
Background	PTPN6 gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and negatively regulates ERK2 and p38 MAP-kinases activity. The PTPN6 was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway.
Immunogen Region	1-577
Tag	N-terminal GST-tag
Formulation	25 mM Tris-HCl, pH 8.0, 75 mM NaCl, 0.05% Tween-20, 50% glycerol, 2 mM EDTA, 1 mM DTT, 10 mM glutathione.
Species	Human
Application	Useful for the study of enzyme kinetics and regulation, to dephosphorylate target substrates and for screening inhibitors.
Notes	50 mM HEPES, pH 7.4, 2 mM EDTA, 3 mM DTT, 100 mM NaCl, 50 mM pNPP. Avoid freeze/thaw cycles.
GenBank	NM_080549
Mw(kda)	93 kDa

Synonyms	SHP1; SHP-1; HCP; HCPH; HPTP1C; PTP-1C; SHP-1L; SH-PTP1
Uniprot	P25440

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	>12 months at -80°C

Reference	1. N.E. Kilgore et al., J. Immunol. 2003, 170:4891-4895. 2. J.V. Ravetch & L.L. Lanier Science 2000, 290: 84-9. 3. C. Duchesne et al. J. Biol. Chem 2003, 278:14274-14283.

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200033	30021	50 ug was 20 ug	$357.50		Add to Cart

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