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Home / Proteins & Peptide

Sestrin 1, FLAG-tag

SKU : BHP18200377

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Mfr.No.	50284
Description	Human Sestrin1, also known as p53-regulated protein PA26 (GenBank Accession No. NM_014454), full length, a.a. 2-551(end), with N-terminal FLAG-tag, MW=65 kDa, expressed in Sf9 insect cells via a baculovirus expression system. Host cell line: Sf9 cells
Background	Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. Sestrin 1 mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mTOR protein. Sestrin 1 in important for antioxidant defense because it regenerates overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation.
Immunogen Region	2-551(end)
Tag	N-terminal FLAG-tag
Formulation	45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 3 mM DTT, 90 g/ml FLAG peptide and 10% glycerol
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	Avoid freeze/thaw cycles.
GenBank	NM_014454
Mw(kda)	65 kDa

Synonyms	Sestrin-1, PA26, SEST1, P53-Regulated Protein PA26
Uniprot	Q9Y6P5

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Lee, J.H., et al. (2010). Science 327(5970): 1223-8. 2. Broderick, G., et al., (2006). Pharmacogenomics 7(3): 407-419. 3. Budanov AV, Karin M. (2008). Cell 134 (3): 451-460. 4. Hay, N. (2008). Cell Metab. 8(3):184-5.

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200377	50284	50 ug	$467.50		Add to Cart

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