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Home / Proteins & Peptide

SDF-1beta/CXCL12, Mouse

SKU : BHP18500446

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Mfr.No.	IX03307, IX03307-10, IX03307-50
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Description	SDF-1 alpha and SDF-1 beta, members of the chemokine alpha subfamily that lack the ELR domain, were initially identified using the signal sequence trap cloning strategy from a mouse bone-marrow stromal cell line. SDF-1 alpha and SDF-1 beta cDNAs encode precursor proteins of 89 and 93 amino acid residues, respectively. Both SDF-1 alpha and SDF-1 beta are encoded by a single gene and arise by alternative splicing. The two proteins are identical except for the four amino acid residues that are present in the carboxy-terminus of SDF-1 beta and absent from SDF-1 alpha. SDF-1/PBSF is highly conserved between species, with only one amino acid substitution between the mature human and mouse proteins. SDF-1/PBSF acts via the chemokine receptor CXCR4 and has been shown to be a chemoattractant for T-lymphocytes, monocytes, pro- and pre-B cells, but not neutrophils. Mice lacking SDF-1 or CXCR4 have been found to have impaired B-lymphopoiesis, myelopoiesis, vascular development, cardiogenesis and abnormal neuronal cell migration and patterning in the central nervous system.Recombinant Mouse SDF-1 beta/CXCL12 produced in CHO cells is a polypeptide chain containing 78 amino acids. A fully biologically active molecule, rm SDF-1beta/CXCL12 has a molecular mass of 8.5 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	8.5 kDa, observed by reducing SDS-PAGE.
Source	CHO
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	The EC50 value of mouse SDF-1?/CXCL12 on Ca2+ mobilization assay in CHO-K1/Galpha15/mCXCR4 cells (human Galpha15 and mCXCR4 stably expressed in CHO-K1 cells) is less than 2.5 ug/ml.

Synonyms	SDF-1 ?, Stromal-Cell Derived Factor-1, CXCL12, PBSF
Sequence	Lys22-Met93 (accession #: P40224)

Purity	95% as analyzed by SDS-PAGE.
Storage	Lyophilized recombinant Mouse SDF-1 beta/CXCL12 remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Mouse SDF-1beta/CXCL12 should be stable up to 1 week at 4°C or up to 3 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500446-1	IX03307-10	10ug	$112		Add to Cart
BHP18500446-2	IX03307-50	50ug	$199		Add to Cart

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