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Home / Proteins & Peptide

SDF-1alpha/CXCL12, Mouse

SKU : BHP18500124

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iXCells Biotechnologies

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Mfr.No.	IX02900, IX02900-1, IX02900-10
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <= -20 °C. Further dilutions should be made in appropriate buffered solutions.
Description	Stromal-Cell Derived Factor-1 alpha/ CXCL12 (SDF-1alpha) and SDF-1beta, members of the chemokine alpha subfamily that lack the ELR domain, were initially identified using the signal sequence trap cloning strategy from a mouse bone-marrow stromal cell line. These proteins were subsequently also cloned from a human stromal cell line as cytokines that supported the proliferation of a stromal cell-dependent pre-B-cell line. SDF-1alpha and SDF-1beta cDNAs encode precursor proteins of 89 and 93 amino acid residues, respectively. Both SDF-1alpha and SDF-1beta are encoded by a single gene and arise by alternative splicing. The two proteins are identical except for the four amino acid residues that are present in the carboxy-terminus of SDF-1beta and absent from SDF-1alpha. SDF-1/PBSF is highly conserved between species, with only one amino acid substitution between the mature human and mouse proteins. SDF-1/PBSF acts via the chemokine receptor CXCR4 and has been shown to be a chemoattractant for T-lymphocytes, monocytes, pro- and pre- B cells, but not neutrophils. Mice lacking SDF-1 or CXCR4 have been found to have impaired B-lymphopoiesis, myelopoiesis, vascular development, cardiogenesis and abnormal neuronal cell migration and patterning in the central nervous system.
Formulation	Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4.
Molecular Weight	Approximately 8.0 kDa, a single non-glycosylated polypeptide chain containing 68 amino acids.
Physical Appearance	Sterile Filtered White lyophilized (freeze-dried) powder.
Source	E. coli
Host	Mouse
Endotoxin Level	Less than 1 EU/ug of rMuSDF-1alpha/CXCL12alpha as determined by LAL method.
Bioactivity	Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 50-100 ng/ml.

Synonyms	Murine Stromal-Cell Derived Factor-1 alpha
Sequence	KPVSLSYRCP CRFFESHIAR ANVKHLKILN TPNCALQIVARLKNNNRQVC IDPKLKWIQE?YLEKALNK

Purity	97 % by SDS-PAGE and HPLC analyses.
Storage	This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500124-1	IX02900-1	1mg	$2621		Add to Cart
BHP18500124-2	IX02900-10	10ug	$199		Add to Cart

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