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Home / Proteins & Peptide

ROR1, Fc-Fusion (IgG1), Avi-Tag

SKU : BHP18201748

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Mfr.No.	79481-1
Description	Human ROR1, also known as receptor tyrosine kinase-like orphan receptor 1, neurotrophic tyrosine kinase, and receptor-related 1 (NTRKR1), GenBank Accession No. NM_005012, a.a 24-403, with C-terminal Avi-TagTM fused to the Fc portion of Human IgG1 and expressed in a HEK293 cell expression system. MW = 71 kDa. This protein runs at a higher apparent M.W. by SDS-PAGE due to glycosylation. host species: mammalian (human) Host species: mammalian (human) Host cell line: HEK293
Background	ROR1 is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors that play a role in the control of most basic cellular processes including cell proliferation, differentiation, migration and metabolism. Many human breast cancers express the ROR1 protein and high-level expression of ROR1 in breast adenocarcinoma is associated with aggressive disease. Silencing expression of ROR1 in human breast cancer cell lines found to express this protein impaired their growth in vitro and also in immune-deficient mice.
Immunogen Region	24-403
Tag	C-terminal Fc-Avi-Tag
Formulation	8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol.
Species	Human
Notes	HiP indicates a high purity protein with>=90% purity as measured by gel filtration. This protein runs at a higher apparent M.W. by SDS-PAGE due to glycosylation. Avoid freeze/thaw cycles.
GenBank	NM_005012
Mw(kda)	71 kDa + glycans

Synonyms	receptor tyrosine kinase-like orphan receptor 1, neurotrophic tyrosine kinase, and receptor-related 1, NTRKR1
Uniprot	Q01973

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Fukuda, T., et al., PNAS. 2007 Dec; 105(8): 3047-3052.2. Hudecek, M., et al., Clinical Cancer Research. 2013 Jun; 19(12): 3109.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18201748	79481-1	100 ug	$352		Add to Cart

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