Human Activated Renin (GenBank Accession No. NM_000537), amino acids 67 - 406 (end) with C-terminal HIS tag, MW=38.6 kDa, expressed in a mammalian expression system.
Specific activity: >= 255 pmol/min/ug.
Background
Renin is a protease that is synthesized by the kidneys. Renin catalyzesthe hydrolysis of angiotensinogen to angiotensin I, which is converted to angiotensin II, ahighly potent vasoconstrictor. Renin inhibitors have been used therapeutically in thetreatment of hypertension (high blood pressure).
Immunogen Region
67-406
Tag
C-terminal His-tag
Formulation
40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 250 mM imidazole,and 20% glycerol.
Species
Human
Notes
Assay was performedusing BPS's Renin Assay kit, cat. # 80211, following the recommended assay protocol.