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Recombinant Vaccinia virus RNA-binding protein E3(E3L)

SKU : BHP10505684

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP322729VAA
Description	The C-terminus binds to and sequesters double-stranded RNA (dsRNA) synthesized during viral infection. This binding acts to 'mask' the dsRNA thereby preventing recognition and subsequent activation of EIF2AK2/PKR. The N-terminus is required for phosphorylation regulation of the translation initiation factor EIF2S1, but without affecting cytosolic protein translation. Blocks the phosphorylation and subsequent activation of IRF3 and IRF7 kinases, that are required for interferon-alpha (IFN-alpha) gene expression. Also inhibits NF-kappa-B activation and the ubiquitin-like protein G1P2/ISG15, which is an early antiviral protein
Alternative Names	p25
Tag	N-terminal 10xHis-tagged and C-terminal Myc-tagged
Regulatory	RUO
Relevance	The C-terminus binds to and sequesters double-stranded RNA (dsRNA) synthesized during viral infection. This binding acts to 'mask' the dsRNA thereby preventing recognition and subsequent activation of EIF2AK2/PKR. The N-terminus is required for phosphorylation regulation of the translation initiation factor EIF2S1, but without affecting cytosolic protein translation. Blocks the phosphorylation and subsequent activation of IRF3 and IRF7 kinases, that are required for interferon-alpha (IFN-alpha) gene expression. Also inhibits NF-kappa-B activation and the ubiquitin-like protein G1P2/ISG15, which is an early antiviral protein
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Protein Name	p25
Expression Region	1-190aa
Mol Weight	28.5 kDa
Nature	Recombinant
Protein Description	Full Length

Uniprot	P21081, P21081
Function	The C-terminus binds to and sequesters double-stranded RNA (dsRNA) synthesized during viral infection. This binding acts to 'mask' the dsRNA thereby preventing recognition and subsequent activation of EIF2AK2/PKR. The N-terminus is required for phosphorylation regulation of the translation initiation factor EIF2S1, but without affecting cytosolic protein translation. Blocks the phosphorylation and subsequent activation of IRF3 and IRF7 kinases, that are required for interferon-alpha (IFN-alpha) gene expression. Also inhibits NF-kappa-B activation and the ubiquitin-like protein G1P2/ISG15, which is an early antiviral protein (By similarity).
Protein Families	Poxviridae E3 protein family
Research Area	Others
Weight	28.5 kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 85% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
Storage Buffer	Tris-based buffer,50% glycerol

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SKU	Supplier No.	Size	Your price	Quantity
BHP10505684	CSB-EP322729VAA	1mg	$2466		Add to Cart
BHP10505684	CSB-EP322729VAA	100ug	$729		Add to Cart
BHP10505684	CSB-EP322729VAA	20ug	$388		Add to Cart

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