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Home / Proteins & Peptide

Recombinant SARS-CoV-2 Spike S1+S2 ECD (?HV69-70,?Y144,N501Y,A570D,D614G,P681H,T716I,S982A,D1118H)(His Tag)

SKU : BHP10306346

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSV030346
Reconstitution	Please refer to the printed manual for detailed information.
Background	The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that SARS-CoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.
Tag	C-His
Formulation	Lyophilized from sterile 20 mM Tris, 300 mM NaCl, 10 % glycerol, pH 8.0.
Species	SARS-CoV-2
Host	Baculovirus-Insect Cells
Accession Number	YP_009724390.1
Endotoxin Level	< 1.0 EU per ug protein as determined by the LAL method.
Accurate Molecular Mass(kd)	134.1 kDa
Protein Description	A DNA sequence encoding the SARS-CoV-2 (2019-nCoV) Spike Protein (S1+S2 ECD) (YP_009724390.1) (Met1-Pro1213(HV69-70 deletion, Y144 deletion, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H)) was expressed with a polyhistidine tag at the C-terminus.

Research Area	Virus related Protein
Sequence	Met1-Pro1213

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Purity	> 85 % as determined by SDS-PAGE.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at< -20°C for 3 months.

Immunological Activity	Measured by its binding ability in a functional ELISA. Immobilized Human ACE2 (mFc tag)(Cat: PKSH031870) at 2 ug/mL (100 uL/well) can bind SARS-CoV-2 (2019-nCoV) Spike S1+S2 ECD (HV69-70 deletion, Y144 deletion, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H)-His(PKSV030346), the EC50 of PKSV030346 is 200-800 ng/mL.

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SKU	Supplier No.	Size	Your price	Quantity
BHP10306346	PKSV030346	100ug	$1105		Add to Cart

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