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Home / Proteins & Peptide

Recombinant Saccharomyces cerevisiae GTP-binding protein YPT1(YPT1)

SKU : BHP10502821

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP360492SVG
Alternative Names	Protein YP2, Rab GTPase YPT1, Transport GTPase YPT1, Protein YP2 ; Rab GTPase YPT1 ; Transport GTPase YPT1
Antigen	YPT1
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. YPT1 regulates the trafficking of secretory vesicles from the endoplasmic reticulum (ER) to the Golgi. Vesicular transport depends on shuttling of YPT1 between membrane and cytosol by GDI1, probably by recycling it to its membrane of origin after a vesicle fusion event. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum. Also involved in the recycling of membrane proteins.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	1-206aa
Mol Weight	39.2kDa
Nature	recombinant
Protein Description	Full Length

Subcellular Location	Endoplasmic reticulum membrane, Peripheral membrane protein, Golgi apparatus membrane, Peripheral membrane protein, Cytoplasm, Preautophagosomal structure membrane, Lipid-anchor, Cytoplasmic side
Uniprot	P01123, P01123
Database Links	KEGG:sce:YFL038C STRING:4932.YFL038C
Function	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. YPT1 regulates the trafficking of secretory vesicles from the endoplasmic reticulum (ER) to the Golgi. Vesicular transport depends on shuttling of YPT1 between membrane and cytosol by GDI1, probably by recycling it to its membrane of origin after a vesicle fusion event. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum. Also involved in the recycling of membrane proteins.
Protein Families	Small GTPase superfamily, Rab family
Research Area	Others
Weight	39.2kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Saccharomyces Cerivisiae (Yeast)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10502821	CSB-EP360492SVG	1mg	$2466		Add to Cart
BHP10502821	CSB-EP360492SVG	100ug	$729		Add to Cart
BHP10502821	CSB-EP360492SVG	20ug	$388		Add to Cart

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