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Home / Proteins & Peptide

Recombinant Rhesus Macaque Leukocyte-associated Immunoglobulin-like Receptor 1/LAIR1/CD305 (C-6His)

SKU : BHP10306222

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSQ050107
Description	Recombinant Rhesus Macaque Leukocyte-Associated Immunoglobulin-Like Receptor 1 is produced by our Mammalian expression system and the target gene encoding Gln22-Try165 is expressed with a 6His tag at the C-terminus.
Alternative Names	Leukocyte-Associated Immunoglobulin-Like Receptor 1; LAIR-1; hLAIR1; CD305; LAIR1
Reconstitution	Please refer to the printed manual for detailed information.
Background	Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) is a single-pass type I membrane protein. LAIR1 expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells, highly in naive T-cells and B-cells. As an inhibitory receptor, LAIR1 plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. LAIR1 plays inhibitory role independently of SH2-containing phosphatases and modulates cytokine production in CD4+ T-cells. It down-regulates IL2 and IFNG production while inducing secretion of transforming growth factor beta, also down-regulates IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. LAIR1 inhibits the differentiation of peripheral blood precursors towards dendritic cells. It also restrains proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells.
Reactivity	Rhesus Macaque
Tag	C-6His
Formulation	Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
Host	Human Cells
Accession Number	A0A0U3SBU1
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Mol Weight	16.6 kDa
Mw(kda)	16.6 kDa

Sequence Info	Gln22-Try165

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	>95% as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10306222	PKSQ050107	10ug	$132		Add to Cart
BHP10306222	PKSQ050107	50ug	$393		Add to Cart

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