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Home / Proteins & Peptide

Recombinant Rat UCHL3/UCH-L3 Protein (His Tag)(Active)

SKU : BHP10305782

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSR030368
Description	A DNA sequence encoding the rat UCHL3 (Q91Y78) (Glu 2-Ala 230) was fused with a polyhistidine tag at the N-terminus.
Alternative Names	rCG_37146;RGD1561196
Reconstitution	Please refer to the printed manual for detailed information.
Background	Ubiquitin carboxyl-terminal hydrolase isozyme L3, also known as UCH-L3, Ubiquitin thioesterase L3 and UCHL3, is a ubiquitin-protein hydrolase which belongs to the peptidase C12 family. It is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. UCHL3 is highly expressed in heart, skeletal muscle, and testis. UCHL1 and UCHL3 are two of the deubiquitinating enzymes expressed in the brain. These phenotypes indicate the importance of UCHL1 and UCHL3 in the regulation of the central nervous system. UCHL3 functions as a de-ubiquitinating enzyme where lack of its hydrolase activity may result in the prominent accumulation of ubiquitinated proteins and subsequent induction of stress responses in skeletal muscle. UCHL3 has also been identified as a tumor-specific antigen in colon cancer.
Reactivity	Rat
Tag	N-His
Formulation	Lyophilized from sterile PBS, pH 7.4
Host	E. coli
Accession Number	Q91Y78
Endotoxin Level	Please contact us for more information.
Bioactivity	Measured by the hydrolysis of UbiquitinAMC. The specific activity is >14000 pmoles/min/ug.
Mol Weight	27.5 kDa
Mw(kda)	27.5 kDa

Sequence Info	Glu 2-Ala 230

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95 % as determined by SDS-PAGE

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10305782	PKSR030368	50ug	$732		Add to Cart

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