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Home / Proteins & Peptide

Recombinant Rat Tie2/TEK Protein (Fc Tag)(Active)

SKU : BHP10305790

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSR030377
Description	A DNA sequence encoding the rat TEK (NP_001099207.1) extracellular domain (Met 4-Leu 743) was fused with the Fc region of human IgG1 at the C-terminus.
Alternative Names	Tie-2;Tie2
Reconstitution	Please refer to the printed manual for detailed information.
Background	TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play critical roles in vascular maturation, maintenance of integrity and remodeling. Targeted mutagenesis of both Tek and its agonistic ligand, Angiopoietin-1, result in embryonic lethality, demonstrating that the signal transduction pathways mediated by this receptor are crucial for normal embryonic development. TEK signaling is indispensable for the development of the embryonic vasculature and suggests that TEK signaling may also be required for the development of the tumor vasculature.
Reactivity	Rat
Tag	C-Fc
Formulation	Lyophilized from sterile PBS, pH 7.4
Host	HEK293 Cells
Accession Number	NP_001099207.1
Endotoxin Level	< 1.0 EU per ?g of the protein as determined by the LAL method
Bioactivity	1. Measured by its binding ability in a functional ELISA.2. Immobilized S1h-3C-mANGPT2 at 10 ug/mL (100 uL/well) can bind ratTEK-Fc.The EC50 of ratTEK-Fc is 0.26-0.62ug/mL.
Mol Weight	108 kDa
Mw(kda)	108 kDa

Sequence Info	Met 4-Leu 743

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95 % as determined by SDS-PAGE

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10305790	PKSR030377	200ug	$732		Add to Cart

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