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Home / Proteins & Peptide

Recombinant Rat Thyroxine 5-deiodinase(Dio3),partial(170:U?missing)

SKU : BHP10501157

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP344617RA
Alternative Names	5DIIIDIOIIIType 3 DIType-III 5'-deiodinase
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing prature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during bryological development.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	37-278aa
Mol Weight	31.5kDa
Nature	recombinant
Protein Description	Partial

Subcellular Location	Cell membrane, Single-pass type II membrane protein, Endosome membrane, Single-pass type II membrane protein
Uniprot	P49897, P49897
Database Links	KEGG:rno:29475 UniGene:Rn.11237
Function	Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.
Protein Families	Iodothyronine deiodinase family
Research Area	Others
Tissue Specificity	Neonatal skin, placenta, skeletal muscle and cerebral cortex.
Weight	31.5kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Rattus Norvegicus (Rat)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10501157	CSB-EP344617RA	1mg	$2466		Add to Cart
BHP10501157	CSB-EP344617RA	100ug	$578		Add to Cart
BHP10501157	CSB-EP344617RA	20ug	$306		Add to Cart

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