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Home / Proteins & Peptide

Recombinant Rat TGFB1/TGF-beta 1 Protein (Active)

SKU : BHP10305828

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSR030419
Description	A DNA sequence encoding the rat TGFB1 (P17246)(Ala279-Ser390) was expressed. Rat and Mouse mature TGFB1 sequences are identical.
Alternative Names	TGF-beta 1;TGFB;TGFbeta
Reconstitution	Please refer to the printed manual for detailed information.
Background	TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-beta 1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-gamma, tumor necrosis factor-alpha and various interleukins. It can also decrease the expression levels of cytokine receptors. Meanwhile, TGF-beta 1 also increases the expression of certain cytokines in T cells and promotes their proliferation, particularly if the cells are immature. TGF-beta 1 also inhibits proliferation and stimulates apoptosis of B cells, and plays a role in controlling the expression of antibody, transferrin and MHC class II proteins on immature and mature B cells. As for myeloid cells, TGF-beta 1can inhibit their proliferation and prevent their production of reactive oxygen and nitrogen intermediates. However, as with other cell types, TGF-beta 1 also has the opposite effect on cells of myeloid origin. TGF-beta 1 is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Once cells lose their sensitivity to TGF-beta1-mediated growth inhibition, autocrine TGF-beta signaling can promote tumorigenesis. Elevated levels of TGF-beta1 are often observed in advanced carcinomas, and have been correlated with increased tumor invasiveness and disease progression.
Reactivity	Rat
Formulation	Lyophilized from sterile PBS, pH 7.4
Host	HEK293 Cells
Accession Number	P17246
Endotoxin Level	< 1.0 EU per ?g of the protein as determined by the LAL method
Bioactivity	Measured by its ability to inhibit cell proliferation of Mv-1-lu mink lung epithelial cells. The ED50 for this effect is 0.2-0.8 ng/mL.
Mol Weight	12.8 kDa
Mw(kda)	12.8 kDa

Sequence Info	Ala279-Ser390

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 90 % as determined by SDS-PAGE

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10305828	PKSR030419	5ug	$154		Add to Cart
BHP10305828	PKSR030419	100ug	-		Add to Cart

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