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Home / Proteins & Peptide

Recombinant Rat Metalloproteinase inhibitor 1(Timp1)

SKU : BHP10502114

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-RP167194r
Alternative Names	Tissue inhibitor of metalloproteinases 1 ,TIMP-1, Tissue inhibitor of metalloproteinases 1 ; TIMP-1
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates th by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Also stimulates steroidogenesis by Leydig and ovarian granuloma cells; procathepsin L is required for maximal activity.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	24-217aa
Mol Weight	25.5kDa
Nature	recombinant
Protein Description	Full Length of Mature Protein

Subcellular Location	Secreted
Uniprot	P30120, P30120
Database Links	KEGG:o:116510 STRING:10116.ENSRNOP00000013745 UniGene:Rn.25754
Function	Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Also stimulates steroidogenesis by Leydig and ovarian granuloma cells; procathepsin L is required for maximal activity.
Pathway	HIF-1 signaling pathway
Protein Families	Protease inhibitor I35 (TIMP) family
Research Area	Others
Weight	25.6kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Rattus Norvegicus (Rat)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10502114	CSB-RP167194r	1mg	$2466		Add to Cart
BHP10502114	CSB-RP167194r	100ug	$578		Add to Cart
BHP10502114	CSB-RP167194r	20ug	$306		Add to Cart

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