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Home / Proteins & Peptide

Recombinant Rat IL-10/Interleukin-10 Protein (Active)

SKU : BHP10305837

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSR030434
Description	A DNA sequence encoding the rat IL10 (NP_036986.2) (Ser19-Asn178) was expressed and purified with an initial Met.
Alternative Names	IL10;Il-10
Reconstitution	Please refer to the printed manual for detailed information.
Background	IL-10 is a anti-inflammatory cytokine which belongs to the IL-10 family. It is produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types, while it is produced primarily by monocytes and to a lesser extent by lymphocytes. IL-10 is mainly expressed in monocytes and Type 2 T helper cells (TH2), mast cells, CD4+CD25+Foxp3+ regulatory T cells, and also in a certain subset of activated T cells and B cells. IL-10 has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. The importance of interleukin 10 for counteracting excessive immunity in the human body is revealed by the fact that patients with Crohn's disease react favorably towards treatment with bacteria producing recombinant IL-10. IL-10 inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. It also displays a potent ability to suppress the antigen-presentation capacity of antigen presenting cells. However, it is also stimulatory towards certain T cells and mast cells and stimulates B cell maturation and antibody production.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Reactivity	Rat
Formulation	Lyophilized from sterile PBS, 10 % glycerol.
Host	E. coli
Accession Number	NP_036986.2
Endotoxin Level	Please contact us for more information.
Bioactivity	Measured in a cell proliferation assay using MC/9-2 mouse mast cells.The ED50 for this effect is typically 2-8 ng/mL.
Mol Weight	18.6 kDa
Mw(kda)	18.6 kDa

Sequence Info	Ser19-Asn178

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 80 % as determined by SDS-PAGE

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10305837	PKSR030434	20ug	$363		Add to Cart

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