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Home / Proteins & Peptide

Recombinant Rat GFRA1/GDNFRA Protein (His Tag)(Active)

SKU : BHP10305810

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSR030398
Description	A DNA sequence encoding the rat GFRA1 (Q62997-1) (Met 1-Leu 445) was expressed, fused with a polyhistidine tag at the C-terminus.
Alternative Names	GFRA1;Gdnfra;Retl1;Trnr1;GFR alpha-1
Reconstitution	Please refer to the printed manual for detailed information.
Background	Glial cell line derived neurotrophic factor (GDNF) Family Receptor Alpha 1 (GFRA1) is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. GFRA1 is a potent survival factor for central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are its binding ligand which are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF promotes the formation of a physical complex between GFRA/GDNFRa and the orphan tyrosin kinase receptor Ret, thereby inducing its tyrosine phosphorylation. The RET is a receptor tyrosine kinase representing the signal-transducing molecule of a multisubunit surface receptor complex for the GDNF, in which GFRA / GDNFRa acts as the ligand-binding component. GDNF, a distantly related member of the transforming growth factor-β (TGF-â) superfamily, and its receptor components: GFRA1, Ret and neural cell adhesion molecule (NCAM) have been recently reported to be expressed in the testis and to be involved in the proliferation regulation of immature Sertoli cells.
Reactivity	Rat
Tag	C-His
Formulation	Lyophilized from sterile PBS, pH 7.4
Host	HEK293 Cells
Accession Number	Q62997-1
Endotoxin Level	< 1.0 EU per ?g of the protein as determined by the LAL method
Bioactivity	Measured in a cell proliferation assay using SH?SY5Y human neuroblastoma cells. The ED50 for this effect is typically 0.2-1 ug/mL in the presence of 40 ng/mL Recombinant Rat GDNF.
Mol Weight	48 kDa
Mw(kda)	48 kDa

Sequence Info	Met 1-Leu 445

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 97 % as determined by SDS-PAGE

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10305810	PKSR030398	100ug	$940		Add to Cart

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