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Home / Proteins & Peptide

Recombinant Rat Ephrin-A1(Efna1)

SKU : BHP10502281

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-YP007460RA
Alternative Names	EPH-related receptor tyrosine kinase ligand 1 ,LERK-1Immediate early response protein B61, EPH-related receptor tyrosine kinase ligand 1 ; LERK-1Immediate early response protein B61
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assbly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of bryonic neuronal growth cone and regulates dendritic spine morphogenesis .
Source	Yeast
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Ephrin-A1; Alternative name(s): EPH-related receptor tyrosine kinase ligand 1; Short name= LERK-1; Immediate early response protein B61; Cleaved into the following chain: 1. Ephrin-A1, secreted form
Expression Region	18-182aa
Mol Weight	21.4kDa
Nature	recombinant
Protein Description	Full Length of Mature Protein

Subcellular Location	Cell membrane, Lipid-anchor, GPI-anchor, SUBCELLULAR LOCATION: Ephrin-A1, secreted form: Secreted
Uniprot	P97553, P97553
Database Links	KEGG:rno:94268 STRING:10116.ENSRNOP00000027920 UniGene:Rn.8427
Function	Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis (By similarity).
Pathway	MAPK signaling pathway; PI3K-Akt signaling pathway; Ras signaling pathway; Rap1 signaling pathway
Protein Families	Ephrin family
Research Area	Others
Weight	21.4kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Rattus Norvegicus (Rat)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10502281	CSB-YP007460RA	1mg	$2474		Add to Cart
BHP10502281	CSB-YP007460RA	100ug	$576		Add to Cart
BHP10502281	CSB-YP007460RA	20ug	$306		Add to Cart

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