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Home / Proteins & Peptide

Recombinant Rat CTHRC1 Protein (His Tag)

SKU : BHP10301642

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSR030148
Description	A DNA sequence encoding the rat Cthrc1 (NP_001258229.1) (Met1-Lys230) was expressed with a polyhistidine tag at the C-terminus.
Alternative Names	CTHRC1
Background	Collagen triple helix repeat-containing protein 1, also known as Protein NMTC1, and CTHRC1, is a secreted protein that is glycosylated and highly conserved from lower chordates to mammals. CTHRC1 expression was not detectable in normal arteries. However, it is transiently expressed in the arterial wall in response to injury where it may contribute to vascular remodeling by limiting collagen matrix deposition and promoting cell migration. A short collagen motif with 12 Gly-X-Y repeats appears to be responsible for trimerization of the CTHRC1 protein and this renders the molecule susceptible to cleavage by collagenase. CTHRC1 overexpression caused a dramatic reduction in collagen type I mRNA and protein levels. Currently available data indicate that Cthrc1 expression in vascular cells regulates transforming growth factor beta responsiveness, thereby impacting transforming growth factor beta target genes, including collagens. Additionally, CTHRC1 increases bone mass as a positive regulator of osteoblastic bone formation and offers an anabolic approach for the treatment of osteoporosis.
Tag	His tag
Regulatory	RUO
Host	Human Cells
Endotoxin Level	< 1.0 EU per μg protein as determined by the LAL method.

Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Buffer	Lyophilized from sterile PBS, pH 7.4
Description	Please refer to the printed manual for detailed information.
Purity	> 90 % as determined by SDS-PAGE.
Expiry Date	Samples are stable for up to twelve months from date of receipt at -70℃

Immunogen Species	Rattus Norvegicus (Rat)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10301642	PKSR030148	100ug	$855		Add to Cart

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