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Home / Proteins & Peptide

Recombinant Rat B7-H6/NCR3LG1 Protein (ECD, Fc Tag)(Active)

SKU : BHP10305697

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSR030136
Description	A DNA sequence encoding the rat NCR3LG1 (XP_006223356.1) (Met1-Ser308) was expressed with the Fc region of human IgG1 at the C-terminus.
Alternative Names	B7H6
Reconstitution	Please refer to the printed manual for detailed information.
Background	Natural cytotoxicity triggering receptor 3 ligand 1(B7-H6) is a glycosylated member of the B7 family of immune costimulatory proteins. Mature human B7-H6 consists of a 238 amino acid (aa) extracellular domain (ECD) that contains one Ig-like V domain and one Ig-like C1 domain, a 21 aa transmembrane segment, and a 171 aa cytoplasmic domain that contains one ITIM, one SH2, and one SH3 motif. Both of the Ig-like domains carry N-linked glycosylation. The Ig-like V domain mediates 1:1 stoichiometric binding of B7-H6 to NKp30 expressed on NK cells. It does not show binding to NKp44, NKp46, or NKG2D. Ligation of NKp30 by B7-H6 induces NK cell activation and target cell cytolysis. B7-H6 is expressed on a wide range of hematopoietic, carcinoma, and melanoma tumor cells, which is consistent with the detection of NKp30 binding sites on many tumors.
Reactivity	Rat
Tag	C-Fc
Formulation	Lyophilized from sterile PBS, pH 7.4
Host	HEK293 Cells
Accession Number	XP_006223356.1
Endotoxin Level	< 1.0 EU per ?g protein as determined by the LAL method.
Bioactivity	1.Measured by its binding ability in a functional ELISA. 2.Immobilized rat NCR3-His at 10ug/mL (100uL/well) can bind rat B7-H6-Fc , the EC50 of rat B7-H6 -Fc is 1-20ng/mL.
Mol Weight	60.4 kDa
Mw(kda)	60.4 kDa

Sequence Info	Met1-Ser308

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95 % as determined by SDS-PAGE

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10305697	PKSR030136	50ug	$454		Add to Cart

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