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Home / Proteins & Peptide

Recombinant Pig Interleukin-4 receptor subunit alpha(IL4R),partial

SKU : BHP10505406

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-YP771258PIa4
Description	Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2
Alternative Names	CD_antigen: CD124
Tag	N-terminal 6xHis-sumostar-tagged
Regulatory	RUO
Relevance	Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2
Source	Yeast
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	CD_antigen: CD124
Expression Region	33-240aa
Mol Weight	40.2 kDa
Nature	Recombinant
Protein Description	Partial

Subcellular Location	Membrane, Single-pass type I membrane protein
Uniprot	Q863Z5, Q863Z5
Database Links	KEGG:ssc:397614 STRING:9823.ENSSSCP00000008346 UniGene:Ssc.17244
Function	Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity).
Pathway	Jak-STAT signaling pathway; PI3K-Akt signaling pathway; Hematopoietic cell lineage; Th1 and Th2 cell differentiation; Th17 cell differentiation
Protein Families	Type I cytokine receptor family, Type 4 subfamily
Research Area	Cancer
Weight	40.2 kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 85% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer，50% glycerol

Immunogen Species	Sus Scrofa (Pig)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10505406	CSB-YP771258PIa4	500ug	$1916		Add to Cart
BHP10505406	CSB-YP771258PIa4	100ug	$694		Add to Cart
BHP10505406	CSB-YP771258PIa4	20ug	$368		Add to Cart

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