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Home / Proteins & Peptide

Recombinant Mouse Y-box-binding protein 1(Ybx1)

SKU : BHP10502536

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-YP026247MO
Alternative Names	CCAAT-binding transcription factor I subunit A ,CBF-ADNA-binding protein B ,DBPBEnhancer factor I subunit A ,EFI-AY-box transcription factorY-box-binding protein 1 ,YB-1, CCAAT-binding transcription factor I subunit A ; CBF-ADNA-binding protein B ; DBPBEnhancer factor I subunit A ; EFI-AY-box transcription factorY-box-binding protein 1 ; YB-1
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Mediates pre-mRNA alternative splicing regulation. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes Cytoplasmic domain mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as HLA class II genes. Regulates the transcription of numerous genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds preferentially to 5'-[CU]CUGCG-3' motif in vitro .The secreted form acts as an Extracellular domain mitogen and stimulates cell migration and proliferation.
Source	Yeast
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Nuclease-sensitive element-binding protein 1; Alternative name(s): CCAAT-binding transcription factor I subunit A; Short name= CBF-A; DNA-binding protein B; Short name= DBPB; Enhancer factor I subunit A; Short
Expression Region	2-322aa
Mol Weight	37.6kDa
Nature	recombinant
Protein Description	Full Length of Mature Protein

Subcellular Location	Cytoplasm, Nucleus, Cytoplasmic granule, Secreted
Uniprot	P62960, P62960
Database Links	KEGG:mmu:22608 STRING:10090.ENSMUSP00000078589 UniGene:Mm.258204
Function	Mediates pre-mRNA alternative splicing regulation. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as HLA class II genes. Regulates the transcription of numerous genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds preferentially to 5'-[CU]CUGCG-3' motif in vitro (By similarity).
Research Area	Others
Tissue Specificity	Expressed at high levels in the testis. Present in the mRNP particles that mediate the storage and masking of mRNAs during spermiogenesis.
Weight	37.6kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Mus Musculus (Mouse)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10502536	CSB-YP026247MO	500ug	$1593		Add to Cart
BHP10502536	CSB-YP026247MO	100ug	$576		Add to Cart
BHP10502536	CSB-YP026247MO	20ug	$306		Add to Cart

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