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Home / Proteins & Peptide

Recombinant Mouse Stromal cell-derived factor 1 protein(Cxcl12) (Active)

BHP10500133
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Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
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Subcellular Location Secreted
Uniprot P40224, P40224
Database Links

KEGG:mmu:20315

STRING:10090.ENSMUSP00000072800

UniGene:Mm.303231
Function Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells (By similarity). Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.
Pathway Chemokine signaling pathway; NF-kappa B signaling pathway; Leukocyte transendothelial migration
Protein Families Intercrine alpha (chemokine CxC) family
Research Area Immunology
Tissue Specificity Highest expression levels detected in kidney, liver, spleen and muscle. Isoform Alpha is expressed ubiquitously but at varying levels, while isoform Beta displays tissue-specific expression, with expression detected in kidney, liver, heart, spleen and mus
Weight 8.5 kDa
Buffer 0.2 µm filtered PBS, pH 7.4,lyophilized
Purity >97% as determined by SDS-PAGE and HPLC.
Storage Buffer 0.2 μm filtered PBS, pH 7.4 ,lyophilized
Immunogen Species Mus Musculus (Mouse)
SKU Supplier No. Size Your price Quantity
BHP10500133 CSB-AP001171MO 500ug $2618
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BHP10500133 CSB-AP001171MO 100ug $1166
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BHP10500133 CSB-AP001171MO 10ug $354
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