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Recombinant Mouse Receptor-interacting serine/threonine-protein kinase 1(Ripk1)

BHP10506108
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Email
[email protected]
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Subcellular Location Cytoplasm, Cell membrane
Uniprot Q60855
Database Links

KEGG:mmu:19766

STRING:10090.ENSMUSP00000021844

UniGene:Mm.374799
Function Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex (By similarity). Interacts with ARHGEF2 (By similarity).
Pathway NF-kappa B signaling pathway; TNF signaling pathway; Apoptosis; Necroptosis; NOD-like receptor signaling pathway; Toll-like receptor signaling pathway
Protein Families Protein kinase superfamily, TKL Ser/Thr protein kinase family
Research Area Cancer
Tissue Specificity Found at low levels in all tissues.
Purity Greater than 85% as determined by SDS-PAGE.
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
Storage Buffer Tris-based buffer，50% glycerol
Immunogen Species Mus Musculus (Mouse)
SKU Supplier No. Size Your price Quantity
BHP10506108 CSB-EP720181MOa2 100ug $419
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BHP10506108 CSB-EP720181MOa2 20ug $224
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