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Home / Proteins & Peptide

Recombinant Mouse [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial (Pdk3),partial

SKU : BHP10503524

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP852852MO
Alternative Names	Pyruvate dehydrogenase kinase isoform 3
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species
Source	E.coli
Abbreviation	Pdk3
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial; EC= 2.7.11.2; Alternative name(s): Pyruvate dehydrogenase kinase isoform 3
Expression Region	131-362aa
Mol Weight	30.3kDa
Nature	recombinant
Protein Description	Partial

Subcellular Location	Mitochondrion matrix
Uniprot	Q922H2, Q922H2
Database Links	KEGG:mmu:236900 STRING:10090.ENSMUSP00000036604 UniGene:Mm.12775
Function	Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species (By similarity).
Protein Families	PDK/BCKDK protein kinase family
Research Area	Signal Transduction
Weight	29.75kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Mus Musculus (Mouse)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10503524	CSB-EP852852MO	1mg	$2466		Add to Cart
BHP10503524	CSB-EP852852MO	100ug	$578		Add to Cart
BHP10503524	CSB-EP852852MO	20ug	$306		Add to Cart

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