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Home / Proteins & Peptide

Recombinant Mouse PTPN2/PTPT Protein (aa 2-314, His Tag)(Active)

SKU : BHP10305085

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSM040482
Description	A DNA sequence encoding the mouse PTPN2 (Q06180-1) (Ser 2-Asn 314) was fused with a polyhistidine tag at the N-terminus.
Alternative Names	AI325124;Ptpt;TC-PTP
Reconstitution	Please refer to the printed manual for detailed information.
Background	Tyrosine-protein phosphatase non-receptor type 2, also known as T-cell protein-tyrosine phosphatase, PTPN2 and PTPT, is a cytoplasm protein which belongs to the protein-tyrosine phosphatase family and Non-receptor class 1 subfamily. Members of the protein tyrosine phosphatase ( PTP ) family share a highly conserved catalytic motif, which is essential for the catalytic activity. TC-PTP / PTPN2 is a cytosolic tyrosine phosphatase that functions as a negative regulator of a variety of tyrosine kinases and other signaling proteins. The expression of TC-PTP / PTPN2 plays a role of tumor suppressor and may modulate response to treatment. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. TC-PTP / PTPN2 is an enzyme that is essential for the proper functioning of the immune system and that participates in the control of cell proliferation, and inflammation. TC-PTP / PTPN2 was identified as a negative regulator of NUP214-ABL1 kinase activity.
Reactivity	Mouse
Tag	N-His
Formulation	Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 8.0, 20% gly, 0.1mM TCEP
Host	Baculovirus-Insect Cells
Accession Number	Q06180-1
Endotoxin Level	< 1.0 EU per ?g of the protein as determined by the LAL method.
Bioactivity	Measured by its ability to dephosphorylate a phosphotyrosine residue in an EGF receptor 988-998 phosphopeptide substrate, R&D Systems, Catalog # ES006.The specific activity is > 15 nmoles/min/ug.
Mol Weight	38.7 kDa
Mw(kda)	38.7 kDa

Sequence Info	Ser 2-Asn 314

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 90 % as determined by SDS-PAGE

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10305085	PKSM040482	100ug	$940		Add to Cart

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