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Home / Proteins & Peptide

Recombinant Mouse PTK6/Brk Protein (His & GST Tag)(Active)

SKU : BHP10305025

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSM040298
Description	A DNA sequence encoding the mouse PTK6 (Q64434) (Met1-Val451) was expressed with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Alternative Names	BRK;Sik;tks;Tksk
Reconstitution	Please refer to the printed manual for detailed information.
Background	Tyrosine kinase (PTKs) is a protein that carry out tyrosine phosphorylation, which play a fundamental role in cell proliferation, survival, adhesion, and motility and have also been demenstrated to mediate malignant cell transformation. Overexpression of this protein in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Two classes of PTKs are present in cells: the transmembrane receptor PTKs and the non-receptor PTKs. Tyrosine kinase(PTKs)-6/ BRK is a cytoplasmic non-receptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Tyrosine kinase(PTKs)-6/ BRK has been shown to undergo autophosphorylation. It has been found that the constitutive expression of the tyrosine kinase(PTKs)-6/ BRK is in a large proportion of cutaneous T-cell lymphomas and other transformed T- and B-cell populations. State BRK expression was also induced in normal T-cells. In clinical, the cytoplasmic tyrosine kinase PTK6 (BRK) shows elevated expression in approximately two-thirds of primary breast tumours, and is implicated in EGF receptor-dependent signalling and epithelial tumorigenesis.
Reactivity	Mouse
Tag	N-His-GST
Formulation	Supplied as sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% glycerol
Host	Baculovirus-Insect Cells
Accession Number	Q64434
Endotoxin Level	< 1.0 EU per ?g of the protein as determined by the LAL method.
Bioactivity	The specific activity was determined to be 5 nmol/min/mg using poly (Glu, Tyr) 4:1 as substrate.
Mol Weight	79.8 kDa
Mw(kda)	79.8 kDa

Sequence Info	Met1-Val451

Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Stotage Note	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Purity	> 90 % as determined by SDS-PAGE

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10305025	PKSM040298	50ug	$717		Add to Cart

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