PDGFRa (platelet-derived growth factor receptor A) is a member of the PDGFR family of membrane receptors with intrinsic tyrosine kinase activity. Aberrant expression of PDGFRa has been linked to developmental abnormalities in vertebrate models and has been implicated in multiple disease states in humans. There is widespread expression of PDGFRa in renal cell types involved in fibrotic and sclerosing processes. PDGF and its receptor PDGFRa are inducers of fibrosis in the repair phase of inflammatory bowel disease and they may also be involved in the active inflammatory phase .
For research use only. Not for diagnostic or therapeutic use.
Accession Number
NM_011058
Bioactivity
The specific activity of PDGFRa was determined to be 14 nmol /min/mg as per activity assay protocol.
Gene Name
PDGFRa
Purity
70% - 90%
Storage
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Reviews of Recombinant Mouse PDGFR alpha (N-GST tag)