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Home / Proteins & Peptide

Recombinant Mouse NKG2DL/ULBP-1 Protein (His Tag)

SKU : BHP10305363

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSM041116
Description	Recombinant Mouse UL16 Binding Protein-1/NKG2D ligand 1 is produced by our Mammalian expression system and the target gene encoding Pro26-Thr211 is expressed with a 6His tag at the C-terminus.
Alternative Names	ULBP1; RAET1I; NKG2DL1
Reconstitution	Please refer to the printed manual for detailed information.
Background	Mouse ULBP1, also known as RAET1I and NKG2DL1, is a member of the ULBP/RAET1 gene family. ULBP1 plays an important role in immune responses, especially in cancer and infectious diseases, and is well-known to bind to NKG2D together with at least ULBP 2 and 3. These proteins are distantly related to major histocompatibility class I (MHC I) molecules, possessing the alpha 1 and alpha 2 Ig-like domains, but lacking the alpha 3 domain. Unlike MHC Class I, they have no capacity to bind peptide or interact with beta2-microglobulin. It can activate multiple signaling pathways in primary NK cells, gamma delta T cells, and CD8+ alpha beta T cells, resulting in the production of cytokines and chemokines.ULBP1 is expressed in wide range of tissues including heart, brain, lung, liver, bone marrow and some tumor cells, T-cells, B-cells, As an unconventional member of the MHC class I family, ULBP1 is able to interact with soluble CMV glycoprotein UL16 in CMV infected cells. The interaction with UL16 blocked the interaction with the NKG2D receptor, and thus might escape the immune surveillance. Furthermore, UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. The ULBP1 regulation may have implications for development of new therapeutic strategies against cancer cells.
Reactivity	Mouse
Tag	C-6His
Formulation	Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Host	Human Cells
Accession Number	Q8HWA3
Endotoxin Level	< 1.0 EU per ?g as determined by the LAL method.
Mol Weight	22.3 kDa
Mw(kda)	22.3 kDa

Sequence Info	Pro26-Thr211

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95 % as determined by SDS-PAGE

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10305363	PKSM041116	10ug	$111		Add to Cart
BHP10305363	PKSM041116	50ug	$297		Add to Cart

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