NEK1 or NIMA (never in mitosis gene a)-related kinase 1 is a serine/threonine kinase involved in cell cycle regulation and is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. NEK1 is involved early in the DNA damage response pathway . NEK1 cycles through the nucleus via its nuclear localization and export signals . NEK1 protein participates in different signaling pathways to regulate diverse cellular processes and plays an important role in the kidney where it has opened a new avenue for studying cystogenesis and identifying possible modes of therapy.
For research use only. Not for diagnostic or therapeutic use.
Accession Number
NM_175089
Bioactivity
The specific activity of NEK1 was determined to be 70 nmol /min/mg as per activity assay protocol.
Gene Name
NEK1
Purity
70% - 90%
Storage
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.