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Home / Proteins & Peptide

Recombinant Mouse MCP-2 (CCL8)

SKU : BHP10900301

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Z200397
Alternative Names	Mcp2 ; Scya8 ; C-C motif chemokine 8 ; Monocyte chemotactic protein 2 ; MCP2 ; Small-inducible cytokine A8
Antigen	CCL8
Description	Monocyte chemotactic protein (MCP-2) is a C-C chemokine. It shares over 60% amino acid identity with MCP-1 and MCP- 3 and has about 30% identity with other C-C chemokines MIP-1 alpha, RANTES, and MIP-1 beta. MCP-2 is chemotactic for and activates a wide variety of inflammatory cells. Also, its spectrum of action on leukocytes is similar to that of MCP-3. The leukocytes affected are monocytes, T lymphocytes, natural killer cells, basophils, mast cells, and eosinophils - differs from MCP-1 which is not active on eosinophils. MCP-2 has been proposed to interact with multiple C-C chemokine receptors, including those used by MCP-1 and MCP-3. However, since leukocytes express a multiplicity of chemokine receptors with promiscuous binding and functional properties, it is difficult to identify the receptors used by a given ligand on these cells.
Quantity	200 µg
Regulatory	RUO
Source	E. coli
Host	Mouse
Endotoxin Level	<1.0 EU/μg of recombinant protein as determined by the LAL method.
Biological Activity Comment	The ED(50) was determined by the dose-dependent chemo-attraction human PBMC using a range of 10-100 ng/mL.

Weight	9.0 kDa

Description	A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Format	Lyophilized Powder Mouse MCP-2 was lyophilized from a 0.2 μm filtered 20 mM PB solution pH 7.5, 100 mM NaCl.
Purity	>95% as determined by SDS-PAGE
Storage	The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Immunogen Species	Mus Musculus (Mouse)

MSDS	Growth Factors, Cytokines & Kinases MSDS
Other	Growth Factor and Cytokine Brochure

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SKU	Supplier No.	Size	Your price	Quantity
BHP10900301	Z200397	200µg	$530		Add to Cart

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