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Home / Proteins & Peptide

Recombinant Mouse Legumain(Lgmn)

SKU : BHP10503451

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP012903MO
Alternative Names	Asparaginyl endopeptidase, Protease, cysteine 1, Asparaginyl endopeptidase ; Protease, cysteine 1
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Legumain; EC= 3.4.22.34; Alternative name(s): Asparaginyl endopeptidase; Protease, cysteine 1
Expression Region	18-325aa
Mol Weight	38.8kDa
Nature	recombinant
Protein Description	Full Length of Mature Protein

Subcellular Location	Lysosome
Uniprot	O89017, O89017
Database Links	KEGG:mmu:19141 STRING:10090.ENSMUSP00000021607 UniGene:Mm.17185
Function	Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation.
Pathway	Antigen processing and presentation
Protein Families	Peptidase C13 family
Research Area	Immunology
Tissue Specificity	Detected in kidney proximal tubules (at protein level). Ubiquitous. Particularly abundant in kidney and placenta.
Weight	37.48kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Mus Musculus (Mouse)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10503451	CSB-EP012903MO	1mg	$2466		Add to Cart
BHP10503451	CSB-EP012903MO	100ug	$578		Add to Cart
BHP10503451	CSB-EP012903MO	20ug	$306		Add to Cart

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