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Home / Proteins & Peptide

Recombinant Mouse Interleukin-36 alpha protein(Il36a) (Active)

BHP10500060
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Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
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Subcellular Location Secreted
Uniprot Q9JLA2, Q9JLA2
Database Links

KEGG:mmu:54448

STRING:10090.ENSMUSP00000028361

UniGene:Mm.133095
Function Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of proinflammatory cytokines, including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23 in bone marrow-derived dendritic cells (BMDCs). Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by cultured CD4(+) T-cells and splenocytes. May play a role in proinflammatory effects in the lung
Protein Families IL-1 family
Research Area Immunology
Tissue Specificity Highly expressed in embryonic tissue and in tissues containing epithelial cells. Elevated expression levels are detected in chronic kidney disease; expressed inepithelia from the distal convoluted tubules (DCTs) to the cortical collecting ducts (CCDs) in
Weight 18.0 kDa
Buffer 0.2 µm filtered PBS, pH 7.4, 5 % trehalose,lyophilized
Purity >95% as determined by SDS-PAGE and HPLC.
Storage Buffer 0.2 μm filtered PBS, pH 7.4, 5 % trehalose ,lyophilized
Immunogen Species Mus Musculus (Mouse)
SKU Supplier No. Size Your price Quantity
BHP10500060 CSB-AP003421MO 500ug $5442
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BHP10500060 CSB-AP003421MO 100ug $2426
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BHP10500060 CSB-AP003421MO 10ug $354
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