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Home / Proteins & Peptide

Recombinant Mouse Interleukin-17/IL-17 Protein (Active)

SKU : BHP10305214

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSM040953
Description	A DNA sequence encoding the mature form of mouse IL17a (Q62386) (Thr 22-Ala158) was expressed and purified.
Alternative Names	Ctla-8;Ctla8;IL-17;IL-17A;Il17
Reconstitution	Please refer to the printed manual for detailed information.
Background	IL17, also known as IL17a, is a cytokine belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Reactivity	Mouse
Formulation	Lyophilized from sterile PBS, pH 7.4
Host	E.coli
Accession Number	Q62386
Endotoxin Level	Please contact us for more information.
Bioactivity	1. Measured by its binding ability in a functional ELISA.2. Immobilized recombinant mouse IL17a at 10 ug/mL (100 ul/well) can bind human IL17Ra-Fc2h with a linear range of 16-500 ng/mL.
Mol Weight	15.5 kDa
Mw(kda)	15.5 kDa

Sequence Info	Thr 22-Ala158

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 97 % as determined by SDS-PAGE

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10305214	PKSM040953	20ug	$481		Add to Cart
BHP10305214	PKSM040953	100ug	$932		Add to Cart

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