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Home / Proteins & Peptide

Recombinant Mouse Interferon regulatory factor 8(Irf8)

SKU : BHP10500658

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP011823MO
Alternative Names	Interferon consensus sequence-binding protein ,ICSBP, Interferon consensus sequence-binding protein ; ICSBP
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a regulatory role in cells of the immune syst. Involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory elent, followed by cooperative binding of BATF and IRF8 and activation of genes.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Interferon regulatory factor 8; Short name= IRF-8; Alternative name(s): Interferon consensus sequence-binding protein; Short name= ICSBP
Expression Region	1-424aa
Mol Weight	64.2kDa
Nature	recombinant
Protein Description	Full Length

Subcellular Location	Nucleus, Cytoplasm
Uniprot	P23611, P23611
Database Links	KEGG:mmu:15900 STRING:10090.ENSMUSP00000040245 UniGene:Mm.334861
Function	Plays a role as a transcriptional activator or repressor (By similarity). Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes
Protein Families	IRF family
Research Area	Others
Tissue Specificity	Predominantly in lymphoid tissues.
Weight	64.21kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Mus Musculus (Mouse)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10500658	CSB-EP011823MO	1mg	$2466		Add to Cart
BHP10500658	CSB-EP011823MO	100ug	$578		Add to Cart
BHP10500658	CSB-EP011823MO	20ug	$306		Add to Cart

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