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Home / Proteins & Peptide

Recombinant Mouse IFNAR1/IFNAR Protein (His Tag)(Active)

SKU : BHP10305126

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSM040664
Description	A DNA sequence encoding the extracellular domain of mouse IFNAR1 (NP_034638.2) extracellular domain (Met 1-Thr 429) was expressed, with a polyhistidine tag at the C-terminus.
Alternative Names	CD118;Ifar;Ifnar;Ifrc;Infar
Reconstitution	Please refer to the printed manual for detailed information.
Background	Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.
Reactivity	Mouse
Tag	C-His
Formulation	Lyophilized from sterile PBS, pH 7.4
Host	HEK293 Cells
Accession Number	NP_034638.2
Endotoxin Level	< 1.0 EU per ?g of the protein as determined by the LAL method.
Bioactivity	Measured by its ability to inhibit mIFNB1-mediated protection of L929 mouse fibroblast cells infected with vesicular stomatitis virus (VSV) to viral lysis.The ED50 for this effect is typically 0.2-1ug/mL.
Mol Weight	47 kDa
Mw(kda)	47 kDa

Sequence Info	Met 1-Thr 429

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 96 % as determined by SDS-PAGE

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10305126	PKSM040664	100ug	$732		Add to Cart

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