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Recombinant Mouse Heat shock 70KDA protein 1B(Hspa1b)

BHP10502801
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Subcellular Location Cytoplasm, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Uniprot P17879, P17879
Database Links

KEGG:mmu:15511

STRING:10090.ENSMUSP00000128525

UniGene:Mm.372314
Function Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types
Protein Families Heat shock protein 70 family
Research Area Others
Tissue Specificity Testis-specific.
Weight 86kDa
Stotage Note Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer Tris-based buffer，50% glycerol
Purity Greater than 90% as determined by SDS-PAGE.
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer Tris-based buffer,50% glycerol
Immunogen Species Mus Musculus (Mouse)
SKU Supplier No. Size Your price Quantity
BHP10502801 CSB-EP010822MO 1mg $2466
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BHP10502801 CSB-EP010822MO 100ug $578
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BHP10502801 CSB-EP010822MO 20ug $306
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