JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.
Loding Loading ....
Home / Proteins & Peptide

Recombinant Mouse Ephrin-A1(Efna1),partial (Active)

BHP10506640
Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
Get a Quote
Request More Infos
Order Now

Credit card payments now incur a 3% fee.

Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
Get a Quote
Ask Merchant
Request More Infos
Sample Request
Subcellular Location Cell membrane, Lipid-anchor, GPI-anchor, SUBCELLULAR LOCATION: Ephrin-A1, secreted form: Secreted
Uniprot P52793
Database Links

KEGG:mmu:13636

STRING:10090.ENSMUSP00000029566

UniGene:Mm.15675
Function Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.
Pathway MAPK signaling pathway; PI3K-Akt signaling pathway; Ras signaling pathway; Rap1 signaling pathway
Protein Families Ephrin family
Research Area Signal Transduction
Tissue Specificity Expressed in myogenic progenitor cells.
Purity Greater than 90% as determined by SDS-PAGE.
Storage Buffer Lyophilized from a 0.2 μm filtered 1xPBS, pH 7.4
Immunogen Species Mus Musculus (Mouse)
SKU Supplier No. Size Your price Quantity
BHP10506640 CSB-AP005771MO 1mg $1160
Add to Cart
BHP10506640 CSB-AP005771MO 500ug $870
Add to Cart
BHP10506640 CSB-AP005771MO 50ug $136
Add to Cart