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Home / Proteins & Peptide

Recombinant Mouse EPCR Protein (His Tag)

SKU : BHP10305074

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSM040453
Description	A DNA sequence encoding the mouse PROCR (Q64695) extracellular domain (Met 1-Ser 214) was expressed, with a C-terminal polyhistidine tag.
Alternative Names	AI325044;Ccca;Ccd41;Epcr
Reconstitution	Please refer to the printed manual for detailed information.
Background	Endothelial protein C receptor (EPCR), also known as activated protein C receptor (APC receptor) or PROCR, is a receptor for Protein C. Protein C plays an important role in many metabolism processes in humans and other animals after activated by binding to Endothelial protein C receptor (EPCR). Because of the EPCR is found primarily on endothelial cells (cells on the inside of blood vessels), activated protein C is found maily near endothelial cells. Protein C is pleiotropic, with two main functions: anticoagulation and cytoprotection. Which function will be performed depend on whether or not protein C remains bind to EPCR after activated. The anticoagulation occurs when it does not. In this case, protein C functions as an anticoagulant by irreversibly proteolytically inactivating Factor Va and Factor VIIIa, turning them into Factor Vi and Factor VIIIi respectively. When still bound to EPCR, activated protein C performs its cytoprotective effects, acting on the effector substrate PAR-1, protease-activated receptor-1. To a degree, APC's anticoagulant properties are independent of its cytoprotective ones, in that expression of one pathway is not affected by the existence of the other.
Reactivity	Mouse
Tag	C-His
Formulation	Lyophilized from sterile PBS, pH 7.4
Host	HEK293 Cells
Accession Number	Q64695
Endotoxin Level	< 1.0 EU per ?g of the protein as determined by the LAL method.
Mol Weight	23.7 kDa
Mw(kda)	23.7 kDa

Sequence Info	Met 1-Ser 214

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 96 % as determined by SDS-PAGE

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10305074	PKSM040453	50ug	$855		Add to Cart

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