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Home / Proteins & Peptide

Recombinant Mouse CNTNAP2/CASPR2 Protein (His Tag)(Active)

SKU : BHP10305105

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSM040564
Description	A DNA sequence encoding the extracellular domain of mouse CASPR2 (NP_001004357.2) (Met 1-Ser 1262) was expressed, with a C-terminal polyhistidine tag.
Alternative Names	5430425M22Rik;Caspr2;mKIAA0868
Reconstitution	Please refer to the printed manual for detailed information.
Background	CNTNAP2/CASPR2 is a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. CNTNAP2/CASPR2 is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This protein encoding gene is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation. CNTNAP2/CASPR2 may play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. CNTNAP2/CASPR2 Seems to demarcate the juxtaparanodal region of the axo-glial junction.
Reactivity	Mouse
Tag	C-His
Formulation	Lyophilized from sterile PBS, pH 7.4
Host	HEK293 Cells
Accession Number	NP_001004357.2
Endotoxin Level	< 1.0 EU per ?g of the protein as determined by the LAL method.
Bioactivity	Measured by the ability of the immobilized protein to support the adhesionof C6 Rat brain glial cells. Mouse CASPR2 immobilized (0.8 ug/ml, 100 ul/well) will mediate >30 % C6 cell adhesion.
Mol Weight	139 kDa
Mw(kda)	139 kDa

Sequence Info	Met 1-Ser 1262

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95 % as determined by SDS-PAGE

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10305105	PKSM040564	100ug	$855		Add to Cart

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