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Home / Proteins & Peptide

Recombinant Mouse CD31/PECAM1 Protein (His Tag)

SKU : BHP10305534

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSM041295
Description	Recombinant Mouse PECAM-1 is produced by our Mammalian expression system and the target gene encoding Glu18-Lys590 is expressed with a 6His tag at the C-terminus.
Alternative Names	Platelet endothelial cell adhesion molecule; PECAM-1; CD31; Pecam1; Pecam
Reconstitution	Please refer to the printed manual for detailed information.
Background	Platelet endothelial cell adhesion molecule (PECAM-1, CD31) is a type I transmembrane glycoprotein adhesion molecule in the immunoglobulin superfamily. PECAM-1 is concentrated at cell junctions and is required for transendothelial migration (TEM). The extracellular domain (ECD) of PECAM-1 has ten potential N-linked glycosylation sites and six C2-type Ig-like domains, the first of which is critical for adhesion and extravasation. The cytoplasmic domain contains immunoregulatory tyrosine-based inhibitory and switch motifs (ITIM, ITSM) that mediate both inhibition and activation via phosphotyrosine-mediated engagement of SH2-containing signaling molecules. Expression is restricted to cells involved in circulation, especially endothelial cells, platelets, monocytes, neutrophils and lymphocyte subsets. PECAM-1 participates with other adhesion molecules in some functions, but is the critical molecule for TEM. Homotypic PECAM-1 adhesion in trans, combined with cycling of PECAM-1 to and from surface-connected endothelial cell vesicles, leads leukocytes across endothelial tight junctions.
Reactivity	Mouse
Tag	C-His
Formulation	Lyophilized from a 0.2 um filtered solution of PBS, pH7.4.
Host	Human Cells
Accession Number	Q08481
Endotoxin Level	< 1.0 EU per ?g as determined by the LAL method.
Mol Weight	63.4 kDa
Mw(kda)	63.4 kDa

Sequence Info	Glu18-Lys590

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95% as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10305534	PKSM041295	10ug	$111		Add to Cart
BHP10305534	PKSM041295	50ug	$297		Add to Cart

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