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Home / Proteins & Peptide

Recombinant Mouse Cathepsin L/CTSL Protein (aa 1-334, His Tag)

SKU : BHP10305198

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSM040915
Description	A DNA sequence encoding the mouse CTSL (P06797) (Met 1-Asn 334) was expressed, with a C-terminal polyhistidine tag.
Alternative Names	Cathepsin L1; Major excreted protein; p39 cysteine proteinase; Ctsl1;1190035F06Rik
Reconstitution	Please refer to the printed manual for detailed information.
Background	Cathepsin L is a lysosomal cysteine protease that plays a major role in intracellular protein catabolism, and is potent in degrading collagen, laminin, elastin, as well as alpha-1 protease inhibitor and other structural proteins of basement membranes. It is secreted by liver flukes at all stages of their development in the mammalian host, are believed to play important roles in facilitating parasite migration (tissue degradation), feeding and immuno-evasion. Like many proteases, Cathepsin L is synthesized as an inactive preproenzyme, and cleavage of the 96-residue proregion is necessary to generate the fully active 221-residue mature enzyme. Studies have demonstrated that cleavage of the proregion occur autocatalytically under acidic conditions. The enzyme takes part in nutrient acquisition by catabolizing host proteins to absorbable peptides, facilitates the migration of the parasite through the host intestine and liver by cleaving interstitial matrix proteins such as fibronectin, laminin and native collagen and is implicated in the inactivation of host immune defenses by cleaving immunoglobulins. Recently, Cathepsin L has been shown to suppress Th1 immune response in infected laboratory animals making them susceptible to concurrent bacterial infections. Cathepsin L is synthesized in large amounts and secreted by many malignantly transformed cells, and induced by growth factors and tumor promoters. In addition to its role in protein degradation, evidence has accumulated for the participation of Cathepsin L in various physiological and pathological processes, such as tumor invasion and metastasis, bone resorption, spermatogenesis, and arthritis. Accordingly, Cathepsin L may prove useful as a diagnostic or prognostic marker of human tumor malignancy.
Reactivity	Mouse
Tag	C-His
Formulation	Lyophilized from sterile 20mM Tris, 150mM NaCl, pH 7.5
Host	HEK293 Cells
Accession Number	P06797
Endotoxin Level	< 1.0 EU per ?g of the protein as determined by the LAL method.
Mol Weight	37.3 kDa
Mw(kda)	37.3 kDa

Sequence Info	Met 1-Asn 334

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 90 % as determined by SDS-PAGE

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10305198	PKSM040915	50ug	$867		Add to Cart

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