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Recombinant Mouse Apoptosis regulator Bcl-2(Bcl2),partial

SKU : BHP10504062

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP002611MO
Antigen	BCL2
Tag	N-terminal 6xHis-tagged
Description	Suppresses apoptosis in a variety of cell systs including factor-dependent lymphohatopoietic and neural cells. Regulates cell death by controlling the mitochondrial mbrane permeability. Appears to function in a feedback loop syst with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
Regulatory	RUO
Relevance	Suppresses apoptosis in a variety of cell systs including factor-dependent lymphohatopoietic and neural cells. Regulates cell death by controlling the mitochondrial mbrane permeability. Appears to function in a feedback loop syst with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	5-205aa
Mol Weight	26.7kDa
Nature	Recombinant
Protein Description	Partial

Subcellular Location	Mitochondrion outer membrane, Single-pass membrane protein, Nucleus membrane, Single-pass membrane protein, Endoplasmic reticulum membrane, Single-pass membrane protein
Uniprot	P10417, P10417
Database Links	KEGG:mmu:12043 STRING:10090.ENSMUSP00000108371 UniGene:Mm.257460
Function	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release
Pathway	Estrogen signaling pathway; Hedgehog signaling pathway; HIF-1 signaling pathway; Jak-STAT signaling pathway; PI3K-Akt signaling pathway; Focal adhesion; NF-kappa B signaling pathway; Apoptosis; Autophagy; Protein processing in endoplasmic reticulum; Necroptosis; NOD-like receptor signaling pathway; AGE-RAGE signaling pathway in diabetic complications; ER Stress pathway; Neurotrophin signaling pathway
Protein Families	Bcl-2 family
Research Area	Others
Tissue Specificity	Expressed in a variety of tissues.
Weight	26.7 kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Mus Musculus (Mouse)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10504062	CSB-EP002611MO	1mg	$2466		Add to Cart
BHP10504062	CSB-EP002611MO	100ug	$578		Add to Cart
BHP10504062	CSB-EP002611MO	20ug	$306		Add to Cart

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