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Home / Proteins & Peptide

Recombinant Mouse Activin RIIA/ACVR2A Protein (His & Fc Tag)(Active)

SKU : BHP10305107

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSM040585
Description	A DNA sequence encoding the extracellular domain of mouse ACVR2A (NP_031422.3) (Met 1-Pro 134) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
Alternative Names	ActrIIa;Acvr2;TactrII
Reconstitution	Please refer to the printed manual for detailed information.
Background	ACVR2A and ACVR2B are two activin type II receptors. ACVR2A has been shown to interact with INHBA, SYNJ2BP and ACVR1B. The bovine ACVR2A gene encodes a protein of 513 amino acids which is highly homologous (approximately 98% identity) to the rat, mouse, and human ACVR2A proteins. Inactivation of ACVR2A is a common event in prostate cancer cells suggesting it may play an important role in the development of prostate cancer. The ACVR2A gene is a putative tumor suppressor gene that is frequently mutated in microsatellite-unstable colon cancers (MSI-H colon cancers). Frameshift mutation of ACVR2A may contribute to MSI-H colon tumorigenesis via disruption of alternate TGF-beta effector pathways.
Reactivity	Mouse
Tag	C-His-Fc
Formulation	Lyophilized from sterile PBS, pH 7.4
Host	HEK293 Cells
Accession Number	NP_031422.3
Endotoxin Level	< 1.0 EU per ?g of the protein as determined by the LAL method.
Bioactivity	Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation.The ED50 for this effect is typically 20-60 ng/mL in the presence of 10 ng/mL recombinant Activin A.
Mol Weight	41.4 kDa
Mw(kda)	41.4 kDa

Sequence Info	Met 1-Pro 134

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 97 % as determined by SDS-PAGE

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10305107	PKSM040585	200ug	$1210		Add to Cart

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