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Home / Proteins & Peptide

Recombinant Leptin, Rat

SKU : BHP11300107

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Mfr.No.	BK0120‐1mg
Alternative Names	Obesity protein (OB)
Description	Leptin is a cytokine belonging to the Interleukin 6 family, and has a four-helix bundle structure. Leptin is encoded by the ob gene, and produced and secreted by white adipose tissue. The receptors of Leptin are Type I cytokine receptors, which exist in two different forms: a short form expressed in multiple tissues, and a long form expressed exclusively in the central nervous system (CNS). Upon binding to Leptin, the receptors activate the JAK/STAT3 pathway and PI3K, and stimulate transcriptional programs that regulate feeding behavior, metabolic rate, endocrine axes, and glucose fluxes. The deficiency of Leptin in human and mouse causes morbid obesity, diabetes, and neuroendocrine anomalies. Leptin also has effects on reproduction and immunity. In summary, Leptin is a pivotal cytokine controlling energy balance, and as such has profound effects on human health. Recombinant rat Leptin (rrLeptin) produced in E.coli is a single non-glycosylated polypeptide chain containing 147 amino acids. A fully biologically active molecule, rrLeptin has a molecular mass of 16.3 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Regulatory	RUO
Source	Escherichia coli.
Host	Rat
Endotoxin Level	< 0.2 EU/μg, determined by LAL method.
Biological Activity Comment	ED50 < 10 µg/mL, measured by a cell proliferation assay using LoVo cells, corresponding to a specific activity of > 100 units/mg.
Nature	Recombinant

Weight	16.3 kDa, observed by reducing SDS-PAGE.

Description	Reconstituted in ddH2O at 100 μg/mL.
Format	Lyophilized after extensive dialysis against 50 mM Tris, pH8.0. Sterile Filtered White lyophilized (freeze-dried) powder.
Purity	> 95% as analyzed by SDS-PAGE and HPLC.
Storage	Lyophilized recombinant rat Leptin (rrLeptin) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rrLeptin remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.

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SKU	Supplier No.	Size	Your price	Quantity
BHP11300107	BK0120‐1mg	1mg	$252.67		Add to Cart
BHP11300107	BK0120‐1mg	200μg	$173.16		Add to Cart
BHP11300107	BK0120‐1mg	5mg	$730		Add to Cart

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