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Home / Proteins & Peptide

Recombinant IL-18 BP, Human

SKU : BHP11300199

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Mfr.No.	BK0236‐10μg
Alternative Names	Interleukin-18 Binding Protein ; IL18 BP
Antigen	IL-18 BP
Description	Interleukin-18 binding protein, also known as IL-18BP and tadekinig-alfa, is a secreted glycoprotein that contains an Ig-like C2-type domain. It is expressed in heart, lung, placenta and spleen. IL-18BP functions as an inhibitor of the proinflammatory cytokine IL-18. It binds to IL-18, prevents the binding of IL-18 to its receptor, and thus blocks IL-18-induced IFN-gamma production. The complete Ig domain has been shown to mediate the binding and neutralizing properties. IFN-gamma is able to upregulate the expression of IL-18BP, indicating that IL-18 activity is regulated by a feedback mechanism through IL-18BP.
Regulatory	RUO
Source	CHO
Host	Human
Endotoxin Level	< 0.2 EU/μg, determined by LAL method.
Biological Activity Comment	ED50 < 30 ng /ml, measured in a bioassay using KG-1 cells in the presence of 50ng/ml Human IL-18.
Nature	Recombinant

Weight	42-44 kDa, observed by reducing SDS-PAGE.

Description	Reconstituted in ddH2O or PBS at 100 μg/ml.
Format	Lyophilized after extensive dialysis against PBS. Sterile Filtered White lyophilized (freeze-dried) powder.
Purity	> 95% as analyzed by SDS-PAGE and HPLC.
Storage	Lyophilized recombinant Human IL-18BP remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, Human IL-18BP should be stable up to 1 week at 4°C or up to 2 months at -20°C.

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SKU	Supplier No.	Size	Your price	Quantity
BHP11300199	BK0236‐10μg	10μg	$173.16		Add to Cart
BHP11300199	BK0236‐10μg	1mg	$2055.56		Add to Cart
BHP11300199	BK0236‐10μg	50μg	$252.67		Add to Cart

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