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Recombinant Human Zinc finger protein GLI2(GLI2) ,partial

SKU : BHP10504018

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-MP009500HU
Alternative Names	GLI family zinc finger protein 2, Tax helper protein, GLI family zinc finger protein 2 ; Tax helper protein
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Functions as transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992). Functions as transcriptional activator (PubMed:9557682, PubMed:19878745, PubMed:24311597). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856).By similarity1 Publication5 Publications Isoform 1, isoform 2, isoform 3 and isoform 4: Act as transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Bind to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). Are involved in the smoothened (SHH) signaling pathway (PubMed:18455992).3 Publications Isoform 5: Acts as a transcriptional repressor.
Source	Mammalian cell
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	412-641aa
Mol Weight	30.5kDa
Nature	recombinant
Protein Description	Partial

Involvement In Disease	Holoprosencephaly 9 (HPE9); Culler-Jones syndrome (CJS)
Subcellular Location	Nucleus, Cytoplasm, Cell projection, cilium
Uniprot	P10070, P10070
Database Links	HGNC:4318 OMIM:165230 KEGG:hsa:2736 STRING:9606.ENSP00000354586 UniGene:Hs.111867
Function	Functions as transcription regulator in the hedgehog (Hh) pathway
Pathway	Hedgehog signaling pathway; Hippo signaling pathway
Protein Families	GLI C2H2-type zinc-finger protein family
Research Area	Epigenetics and Nuclear Signaling
Tissue Specificity	Expressed in breast cancers (at protein level) (PubMed:26565916). Isoform 1 and isoform 4 are expressed in HTLV-1-infected T-cell lines (at protein level) (PubMed:9557682). Isoform 1 and isoform 2 are strongly expressed in HTLV-1-infected T-cell lines (Pu
Weight	29.4kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10504018	CSB-MP009500HU	100ug	$1400		Add to Cart
BHP10504018	CSB-MP009500HU	20ug	$500		Add to Cart

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