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Home / Proteins & Peptide

Recombinant Human XIAP/BIRC4 Protein (AVI Tag)(Active)

SKU : BHP10302991

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH031510
Description	A DNA sequence encoding the human XIAP (NP_001158.2) (Leu 121-Thr 356) was fused with an AVI tag at the C-terminus, and additonal two amino acids (Gly & Pro) at the N-terminus.
Alternative Names	API3;BIRC4;hIAP-3;hIAP3;IAP-3;ILP1;MIHA;XLP2
Reconstitution	Please refer to the printed manual for detailed information.
Background	E3 ubiquitin-protein ligase XIAP / BIRC4, also known as inhibitor of apoptosis protein 3, X-linked inhibitor of apoptosis protein, and IAP-like protein, is a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. XIAP / BIRC4 functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. XIAP / BIRC4 also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this encoding gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Thought to be the most potent apoptosis suppressor, XIAP / BIRC4, directly binds and inhibits caspases -3, -7 and -9. Survivin, which also binds to several caspases, is up-regulated in a many tumour cell types. Defects in XIAP / BIRC4 are the cause of lymphoproliferative syndrome X-linked type 2 (XLP2). XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.
Reactivity	Human
Formulation	Lyophilized from sterile 25mM Tris, 10mM DTT, 1% glycerol, 0.2M Glutamine Potassium, pH 8.0
Host	E.coli
Accession Number	NP_001158.2
Endotoxin Level	Please contact us for more information.
Bioactivity	Measured by its binding ability in a functional ELISA.Immobilized recombinant human SMAC-His at 10 ug/ml (100 ul/well) can bind recombinant human XIAP-AVI with a linear range of 0.125-1.0 ug/ml.
Mol Weight	29.1 kDa
Mw(kda)	29.1 kDa

Sequence Info	Leu 121-Thr 356

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 75 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10302991	PKSH031510	100ug	$732		Add to Cart

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