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Recombinant Human VRK1 Protein

SKU : BHP10302877

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH031090
Description	A DNA sequence encoding the human VRK1 (Q99986) (Met 1-Lys 396) was expressed and purified with two additional amino acids (Gly & Pro ) at the N-terminus.
Alternative Names	PCH1;PCH1A
Reconstitution	Please refer to the printed manual for detailed information.
Background	VRK1 is a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. Serine/threonine protein kinases are tumor suppressor that controls the activity of AMP-activated protein kinase family members; thereby playing a role in various processes such as cell metabolism; cell polarity; apoptosis and DNA damage response. VRK1 contains 1 protein kinase domain and localizes to the nucleus. VRK1 gene is widely expressed in human tissues and has increased expression in actively dividing cells; such as those in testis; thymus; fetal liver; and carcinomas. As a serine/threonine kinase; VRK1 phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Defects in VRK1 are the cause of pontocerebellar hypoplasia type 1 (PCH1); also called pontocerebellar hypoplasia with infantile spinal muscular atrophy or pontocerebellar hypoplasia with anterior ho cell disease. PCH1 is characterized by an abnormally small cerebellum and brainstem; central and peripheral motor dysfunction from birth; gliosis and anterior ho cell degeneration resembling infantile spinal muscular atrophy.
Reactivity	Human
Formulation	Lyophilized from sterile 20mM Tris; 500mM NaCl; 10% glycerol; pH 7.4
Host	Baculovirus-Insect Cells
Accession Number	Q99986
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Mol Weight	45.6 kDa
Mw(kda)	45.6 kDa

Sequence Info	Met 1-Lys 396

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10302877	PKSH031090	50ug	$634		Add to Cart

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